Okadaic acid sodium salt, Prorocentrum concavum 47 leverantörer

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Okadaic acid is a marine sponge toxin which potently inhibits certain serine/threonine protein phosphatases. This cell permeable inhibitor targets the multiple isoforms of PP1 (IC50 = 10-50 nM), both isoforms of PP2A (IC50 = 0.5 nM) and PP3 (IC50 Okadaic Acid mimics the effects of insulin, enhances transmitter release at neuromuscular junctions, causes vasodilation and is a very potent tumor promoter. Okadaic acid is an extremely useful tool for studying cellular processes that are regulated by phosphorylation. Okadaic Acid is an activator of PKC. Summary: PPM1L, or PP2CE, belongs to the PP2C group of serine/threonine phosphatases, which are distinguished from other phosphatases by their structure, absolute requirement for Mg(2+) or Mn(2+), and insensitivity to okadaic acid.

Okadaic acid

PP2A is completely inhibited at 1-2 nM, compared to greater than 1 µM for PP1 (1). InSolution Okadaic Acid, Prorocentrum sp. CAS 78111-17-8, is a 250 µM solution of Okadaic Acid in DMSO. Potent inhibitor of protein phosphatase 1 (IC50 = 10-15 nM) and 2A (IC50 = … (3). Okadaic acid has also been described as a non-TPA type potent tumor promoter (4). These tumor-promoting properties and its ability to significantly increase protein phosphorylation make okadaic acid a very useful tool for studying cellular processes that are regulated by reversible phosphorylation of proteins (5). Molecular Formula: C 44 H 68 O 13 Okadaic acid is a polyether fatty acid.

Pimiä, V., Kankaanpää, H. och Kononen, K. (1998). ”The first observation of okadaic acid in. Mytilus edulis from the Gulf of Finland”.

Vimentin is hyperphosphorylated in primary human fibroblasts

This cell permeable inhibitor targets the multiple isoforms of PP1 (IC50 = 10-50 nM), both isoforms of PP2A (IC50 = 0.5 nM) and PP3 (IC50 Okadaic acid also enhanced the neurite degeneration of NGF-primed PC12 cells, indicating that continual phosphatase activity is required to maintain neurites. Taken together, these results reveal the presence of an okadaic acid-sensitive pathway in neurite outgrowth and imply that protein phosphatase plays a positive role in regulating the neuritogenic effects of NGE. Okadaic acid significantly increased phosphorylation of CaMKII; indicating a major role of PP1 in CaMKII dephosphorylation. Literature in this Area Tocris offers the following scientific literature in this area to showcase our products.

Nils Nexelius SMHI

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It is easily accumulated by shellfish, mainly bivalve mollusks and fish, and, subsequently, can be consumed by humans causing alimentary intoxications. OA is the main representative diarrheic shellfish poisoning (DSP) toxin and its ingestion induces gastrointestinal symptoms, although it is not considered Okadaic acid, is used as an activator of PKC and inhibitor of PP1 and PP2A phosphatases. The hydrophobic backbone of okadaic acid enables it to enter cells where it stimulates intracellular protein phosphorylation. EuroProxima Okadaic Acid is a competitive enzyme immunoassay for quantitative analysis of domoic acid in scallop, mussel and oyster samples.
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Authors:. 31 Jan 2008 This is the first in a series of nine opinions on the various biotoxins and it addresses one group , okadaic acid (OA) and related toxins that 27 May 2015 Okadaic acid (OA) is a marine polyether cytotoxin that was first isolated from the marine sponge Halichondria okadai. OA is a potent inhibitor of 11 Sep 2012 Showing metabocard for Okadaic acid (HMDB0030441). Jump To Section: IdentificationTaxonomyOntologyPhysical propertiesSpectraBiological Visit ChemicalBook To find more OKADAIC ACID(78111-17-8) information like chemical properties,Structure,melting point,boiling point,density,molecular 1 Jul 2001 The mechanism whereby the universal apoptogen and serine/threonine phosphatase inhibitor okadaic acid (OA) kills cells, is still unclear.

OA was added to the culture media 24 h after cells had been subcultured, and monolayers were maintained for an additional 24-48 h, at which time the number of cells remaining in the ChEBI Name okadaic acid: ChEBI ID CHEBI:44658: Definition A polycyclic ether that is produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish. Lipid metabolism in visceral fat cells is correlated with metabolic syndrome and cardiovascular diseases. Okadaic-acid, a 38-carbon fatty acid isolated from the black sponge Halichondria okadai, can stimulate lipolysis by promoting the phosphorylation of several proteins in adipocytes. Okadaic Acid: Equivalent Term Ocadaic Acid: CAS Registry Number 78111-17-8 Definition : A specific inhibitor of phosphoserine/threonine protein phosphatase 1 and 2a.
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